Invasive lobular carcinoma with extracellular mucin as a distinct variant of lobular carcinoma: a case report

Invasive lobular carcinoma with extracellular mucin as a distinct variant of lobular carcinoma: a case report

The differences between invasive lobular and ductal carcinomas affect the diagnostic and therapeutic management for patients with breast cancer. In most cases, this can be accomplished because of distinct histomorphologic features. However, occasionally, this task may become quite difficult, in particular when dealing with the variants of infiltrating lobular carcinoma. Lobular carcinoma has be...

Invasive lobular carcinoma with extracellular mucin production and HER-2 overexpression: a case report and further case studies

Invasive lobular carcinomas (ILC) of breast typically demonstrate intracytoplasmic mucin. We present a unique case of classical type ILC with abundant extracellular mucin and strong ERBB2 (HER2/neu) expression confirmed by immunohistochemistry and fluorescent in situ hybridization. Dual E-cadherin/p120 immunohistochemical stain demonstrated complete loss of membranous E-cadherin and the presenc...

Alveolar variant of invasive lobular carcinoma in a fibroadenoma.

by intense parenchymal background enhancement. Our histopathological findings of invasive adenoid cystic carcinoma confirm the importance of pathological examination of reduction mammoplasty specimens for breast carcinoma screening. It is also clear that a more extensive evaluation should be performed in patients with a history of breast carcinoma. Adequate sampling of reduction specimens is es...

Relapse of invasive lobular carcinoma.

Lobular carcinoma of the breast: a special variant of mucin-secreting carcinoma.

There is currently much speculation over the precise nature of lobular carcinoma in-situ of the breast and its significance. Histochemical study shows that it is rich in sialomucin. This has a characteristic intracellular distribution which distinghishes lobular carcinoma in-situ from cancerization of lobules. The same histochemical features are seen in the infiltrative phase of the tumour. The...